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Can medicines used to treat depression cause drug interactions?

Yes, there are drug interactions of depression medications with other medications. And that’s why while you are on mediation treatment you must reveal to the doctor about all the other medications, natural supplements and herbs that you are taking.   
SSRI medications for depression have serious drug interactions with other antidepressants. And that’s why doctors usually do not combine SSRI antidepressants with other depression medications.  

When there is drug interaction between SSRI antidepressants and antihistamines there might be treatment reversal and the antidepressant may lose its effectiveness. Also, there might be symptoms like chest pain and irregular heart rhythm. It is also seen that interactions of SSRI antidepressants with diabetes medications may lead to imbalance in sugar levels. 

With blood pressure and heart medications it is seen that SSRI antidepressants may lead to toxic effect creating mental confusion, changes in blood pressure levels, angina. 
SSRI has drug interactions also with other psychiatric medications like benzodiazepines, mood stabilizers, anticonvulsants.  
If SSRI antidepressants interact with alcohol then it increases drowsiness. With caffeine and tobacco SSRI may interact and lead to increased toxicity which may be harmful.

Apart from the above interactions there are many other medications which interact with depression medications especially SSRI antidepressants.
 
 
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