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Role of norepinephrine and Serotonin in depression

Serotonin and norepinephrine are known to be two essential neurotransmitters in the brain that work towards the regulation of mental equilibrium. In other words, the adequate presence of these two chemicals is must for gaining control over the erratic mood swings, especially depression. It is for the same reason that the inadequate presence of either of the chemicals lead to occurrence of depression symptoms.

Serotonin in particular forms an indispensable part of many anti-depressants like selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants and serotonin and norepinephrine reuptake inhibitors (SNRIs). Either of these medicines is given to the patient experiencing major or minor bouts of depression. Norepinephrine, on the other hand, is synthesized from a neurotransmitter called dopamine.

The lack of this particular chemical leads to symptoms like mood swings, cognitive problems, overwhelming suicidal thoughts, sexual dysfunction, and low mood. As far as Norepinephrine is concerned, these bouts of depression occur only due to dysfunction of that particular area in the brain where this chemical is present.  

The regular intake of these anti-depressants is suggested to prevent the brain from self-synthesizing or recycling these neurotransmitters. This allows the brain to use more of these mood regulating chemicals and thus relieve depression.
 
 
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